Updated: May 2010
Personal
Tel (Home): 972-3-618-7111
Tel: (Office) 972-9-778-2188
Fax: 972-9-778-0661
E-mail: ronitwe@openu.ac.il
Address: Yavne 3, Ramat Gan
Born: 28.10.1966
Status: Married + 2
Education
| 1995-2000 |
Postdoctoral fellow, Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Israel (with Prof. Yigal Koltin and Prof. Mordechai Choder).
Subject: “TOR dependent signaling pathways in fission yeast” |
| 1991-1995 |
Ph. D., Institute of Cell and Molecular Biology, Edinburgh University, UK.
Supervisor: Prof. Peter Fantes.
Dissertation: “Genetic and molecular analysis of the wis2+ gene in fission yeast”
|
| 1987-1990 |
B.Sc., Faculty of Life Sciences, Tel-Aviv University, Israel |
Areas of Interest
- Cellular growth and cell divisions
- Cellular stress responses
- TOR (Target Of Rapamycin) dependnet signaling
- DNA damage response
- Cellular responses to the anti-cancerous drug rapamycin
Academic Positions
| 2008- |
Guest Lecturer, Department of Natural Sciences, The Open University of Israel |
| 2000- |
Visiting Scientist, Department of Molecular Microbiology and Biotechnology, Tel Aviv University, Israel |
| 2006-2008 |
Lecturer, Marine Sciences, Ruppin Academic Center |
Scholarships and Awards
| 1999-2001 |
Research fellowship, Israel Cancer Research Fund (ICRF) |
| 1997-1999 |
Postdoctoral Scholarship, Rector of Tel-Aviv University |
| 1996 |
Postdoctoral Scholarship, Department of Molecular Microbiology, Tel-Aviv University |
| 1995 |
George S. Wise Postdoctoral Scholarship, Tel-Aviv University |
| 1991-1995 |
Research Students Award, British government ORS award scheme, UK |
| 1991-1995 |
Research Students Scholarship, Darwin Trust, Edinburgh University, UK |
| 1989-1991 |
Student Scholarship, B.Sc. Program for Excellence, Tel-Aviv University |
Sponsored Research
| 2009 |
The Research Authority, The Open University of Israel: “Involvement of the TORC1 and TORC2 complexes in the response to the anticancerous drug, rapamycin” (matching scholarship for an M.Sc. student) |
| 2009 |
The Research Authority, The Open University of Israel: “The cellular roles of the complex TORC2 under DNA replication stress” (matching scholarship for a Ph.D. student) |
| 2009 |
The Research Authority, The Open University of Israel: “Involvement of the fission yeast TOR signaling pathway in the replication and DNA damage response” (matching scholarship for a Ph.D. student) |
| 2009 |
The Research Authority, The Open University of Israel: “Dissection of signal transduction pathways by which TOR complexes regulate growth under normal and DNA damaging conditions” |
| 2008-2009 |
Tel Aviv University Vice President Research Grant for encouraging Research: “The role of TOR in regulation of cell growth and DNA damage response” |
| 2007-2010 |
Association for International Cancer Research, UK (AICR): “Dissection of the signal transduction pathway in which TOR complexes control growth” |
| 2007-2008 |
Tel Aviv University Vice President Research Grant for encouraging Research: “The role of TOR in cell cycle progression” |
| 2007-2008 |
Cancer Biology Research Center of Tel Aviv University (CBRC): “Dissection of the signal transduction pathway in which TOR complexes control growth” |
| 2006-2007 |
Ministry of Health, Israel: “Growth and division control by the target of rapamycin” |
| 2003-2006 |
Israel Science Foundation: “Identifying positive and negative regulators of the TOR signaling pathway in fission yeast” |
| 2002-2005 |
Association for International Cancer Research, UK (AICR):” The TOR Schizosaccharomyces pombe homologues - cellular roles under normal and stress conditions” |
| 2000-2003 |
Israel Science Foundation: “Study of the TOR signaling pathway in fission yeast and implications for rapamycin sensitive pathways” |
| 1999-2002 |
Israel Cancer Research Fund (ICRF): “Study of the TOR signaling pathway in fission yeast” |
| 1999-2003 |
Israel Cancer Research Fund (ICRF): “The mechanism of action and targets of the drug rapamycin in yeast” |
Supervision of Higher Degrees
| 2007- |
Dana Laor, Dept. Molecular Microbiology and Biotechnology, Tel Aviv University, M.Sc. Co-supervision with Prof. Martin Kupiec |
| 2007- |
Miriam Schonbrun, Dept. Molecular Microbiology and Biotechnology, Tel Aviv University, Ph.D. Co-supervision with Prof. Martin Kupiec |
| 2005-2007 |
Miriam Schonbrun, Dept. Molecular Microbiology and Biotechnology, Tel Aviv University, M.Sc. Co-supervision with Prof. Martin Kupiec |
List of Publications
Articles in Refereed Journals
| Weisman, R., Creanor J. and Fantes, P.A. (1996) A multicopy suppressor of a cell cycle defect in S.pombe encodes a heat shock inducible 40 kDa cyclophilin-like protein. EMBO J., 15, 447-456. |
| Weisman, R., Choder, M., and Koltin, Y. (1997) Rapamycin specifically interferes with the developmental response of fission yeast to starvation. J. Bacteriol., 179, 6325-6334. |
| Samejima, I., Mackie, S., Warbrick, E., Weisman, R. and Fantes, P. (1998) The fission yeast mitotic regulator win1+ encodes an MAP kinase kinase kinase that phosphorylates and activates Wis1 MAP kinase kinase in response to high osmolarity. Mol. Biol. Cell 9, 2325-2335. |
| Weisman, R. and Choder, M. (2001) The fission yeast TOR homologue, tor1+, is required for the response to starvation and other stresses via a conserved serine. J. Biol. Chem. 276: 7027-7032. |
| Weisman, R., Finkelstein, S. and Choder, M.(2001) Rapamycin blocks sexual development in fission yeast through inhibition of the cellular function of an FKBP12 homologue. J. Biol. Chem. 276: 24736-24742. |
| Weisman, R., Roitburg I., Nahari, T. and Kupiec, M. (2005) Regulation of leucine uptake by tor1+ in fission yeast is sensitive to rapamycin. Genetics 169:539-550. |
| Weisman, R., Roitburg I., Schonburn M., Harari R. and Kupiec, M. (2007) Opposite effects of Tor1 and Tor2 on nitrogen starvation responses in fission yeast. Genetics 175:1153-1162. |
| Schonburn M. Laor D. Maury L., Bahler J., Kupiec, M. and Weisman R. (2009) TOR complex 2 controls gene silencing, telomere length maintenance and survival under DNA damaging conditions. Mol. Cell Biol. 29: 4584-4594. |
Chapters in Books
Selected Presentations at Scientific Conferences
| 2009 |
Frontiers in Genetics V, Jerusalem, Israel. Poster presentation: The TORC2 complex regulates DNA damage response, gene silencing and telomere length maintenance. |
| 2008 |
Genome stability in health and disease, Jerusalem, Israel. Poster presentation: Tor complexes linking growth with cell divisions. |
| 2008 |
12th International Congress on Yeast (ICY), Kiev, Ukraine. Invited speaker: TORC2 – a new player in DNA damage response. |
| 2008 |
FISEB (Federation of Israel Societies for Experimental Biology), Eilat, Israel. Poster presentation: The TORC2 complex regulates DNA damage response, gene silencing and maintenance of telomere length. |
| 2007 |
Fourth International Fission Yeast Meeting, Copenhagen, Denmark. Poster presentation: Tor1 and Tor2 regulate growth and division in fission yeast. |
| 2005 |
TSC International Research Conference, Cambridge, UK. Tuberous Sclerosis Complex genes - function and dysfunction. Poster presentation: Regulation of leucine uptake by tor1+ in fission yeast is sensitive to rapamycin. |
| 2004 |
University of Copenhagen. Institute of Molecular biology & physiology, Copenhagen, Denmark. Invited speaker: Tor1 regulates growth under normal and stress conditions. |
| 2004 |
British Yeast Group meeting (BYG), Newcastle, UK. Invited speaker: TOR signaling in fission yeast and the response to rapamycin. |
