- Personal
- Education
- Academic Positions
- Other Relevant Positions
- Reference Articles
- Awards
- Teaching Experience
- Presentations and Courses
Personal
Tel: 972-9-7781217
Fax: 972-9-7780661
E-mail: [email protected]
Born: January 11, 1970
Status: Married + 2
Education
2006 – 2008 | Associate Research Scientist, The laboratory of Prof. Richard A. Flavell, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Calcium signaling in the immune system. |
2002 – 2005 | Postdoctoral fellow, The laboratory of Prof. Richard A. Flavell, Department of Immunobiology, Yale University School of Medicine, New Haven, CT, USA. Calcium signaling in the immune system. |
1997 – 2002 | Ph.D, Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. Thesis: The mechanism by which Invariant Chain control B cell maturation. Supervisor: Prof’ Idit Shachar |
1995 – 1996 | M.Sc, (Honors) Department of Cell research and Immunology, Tel-Aviv, Israel. Thesis: Development of a helper free Herpes Simplex Virus Amplicon system for gene therapy. Supervisor: Prof’ Niza Frenkel |
1991 – 1994 | B.Sc, Life Sciences, Tel-Aviv University, Tel Aviv, Israel. |
Academic Positions
2015 – present | Senior Lecturer, Department of Natural and life Sciences, The Open University of Israel, 1 University Road, P.O. Box 808, Ra’anana 4353701, Israel |
2010 – 2015 | Principal Investigator, The Cardiovascular and Thoracic Research Institute, Department of Cardiothoracic Surgery, Hadassah Medical Center, Ein-Kerem, Jerusalem 91120, Israel |
Other Relevant Positions
2009 – 2010 | Senior Scientist, Biokine Therapeutics LTD, Building 13A, Weizmann Science Park, Nes-Ziona, 70400, Israel |
Reference Articles
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Haviv I., Matza D. and Shaul Y. (1998) pX, the HBV Encoded Coactivator, Suppresses the Phenotypes of TBP and TAFII250 Mutants, Genes and Development. 12(8) 1217-26.
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Pierre P., Shachar I., Matza D., Flavell RA and Mellman I. (2000) Invariant chain controls H2-M proteolysis in mouse splenocytes and dendritic cells, Journal of Experimental Medicine 191(6), 1057-1062.
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*Matza D, *Wolstein O, Dikstein R and Shachar I (2001) Invariant chain induces B cell maturation by activating TAFII105-NF-kB transcription program. Journal of Biological Chemistry 276(29), 27203-27206.
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Matza D, Lantner F, Bogoch Y, Flaishon L, Hershkovitz R and Shachar I (2002) Invariant chain induces B cell maturation in a process which is independent of its chaperonic activity. Proceedings in the National Academy of Science USA 99(5), 3018-3023.
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Matza D, Kerem A, Medvedovsky H, Lantner F, and Shachar I (2002) Invariant Chain-Induced B Cell Differentiation Requires Intramembrane Proteolytic Release of the Cytosolic Domain Immunity 17, 549-560.
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Matza D, Kerem A and Shachar I (2003) Invariant chain, a chain of command Trends in Immunology 24(5), 264-268.
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Badou A, Jha MK, Matza D, Mehal WZ, Freichel M, Flockerzi V and Flavell RA (2006) Critical role for the beta regulatory subunits of Cav channels in T Lymphocyte Functions Proceedings in the National Academy of Science USA 103(42), 15529-34.
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*Matza D, *Badou A, Kobayashi KS, Goldsmith-Pestana K, Masuda Y, Komuro A, McMahon-Pratt D, Marchesi VT and Flavell RA, (2008) A scaffold protein, AHNAK1, is required for calcium signaling during T cell activation, Immunity, 28, 1-11.
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Matza D., Badou A., Jha M.K., Willinger T., Antov A., Sanjabi S., Kobayashi K.S., Marchesi V.T. and Flavell R.A. (2009) Requirement for AHNAK1 mediated calcium signaling during T lymphocyte cytolysis, Proceedings in the National Academy of Science USA 106(24), 9785-9790.
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Matza D. and Flavell RA. (2009) Roles of Cav channels and AHNAK1 in T cells-the Beauty and the Beast Immunological Reviews 231, 257-264.
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*Golomb E, *Matza D, Cummings CA, Schwalb H, Kodavanti UP, Schneider A, Houminer E, Korach A, Nyska A, Shapira OM. (2012) Myocardial mitochondrial injury induced by pulmonary exposure to particulate matter in rats. Toxicol Pathol. 2012 Jul; 40(5): 779-88.
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*Badou A., *Jha M.K., *Matza D. and Richard A. Flavell (2013) L-type voltage gated calcium (Cav1) channels in T lymphocytes function, Frontiers in T Cell Biology, 30; 4; 243.
Awards
Sep 2000 | Outstanding oral presentation, EFIS European Immunology Conference award, Poznan, Poland. |
Sep 2000 | Travel award, EFIS European Immunology Conference award, Poznan, Poland. |
Jan 2002 | European Molecular Biology Organization (EMBO) long term postdoctoral fellowship |
Jan 2002 – Jan 2005 | Cancer Research Institute (CRI) foundation postdoctoral fellowship |
Oct 2008 – Oct 2010 | Returning Scientist fellowship, Israel Ministry of Immigrant Absorption |
2011 – 2014 | European Council; Marie Curie International Re-Integration (IRG) Grant; €100,000 |
2015 | Hadassah University Hospital outstanding researcher internal award, 70,000 NIS |
Teaching Experience
1994 – 1996 | Teaching assistant, Cell research and immunology lab course, Tel-Aviv University |
1994 – 1996 | Supervision of 12, 90 hr project, students in the lab of Prof. Niza Frenkel, Department of Cell Research and Immunology, Tel-Aviv University, Tel-Aviv, Israel |
1999 – 2001 | Teaching assistant, Molecular Biology lab techniques, Weizmann Institute of Science, Rehovot, Israel. |
1996 – 2002 | Supervision of 15 M.Sc students in the lab of Prof. Idit Shachar, Department of Immunology, Weizmann Institute of Science, Rehovot, Israel. |
2006 – 2008 | Supervision of lab technician- Molecular Biology techniques, Yale University, New Haven CT, USA. |
2008 – 2011 | Supervision of M.Sc student; Natalya Suchanov |
2012 – present | Supervision of B.Sc students – 320 hour projects. Since 2012, I supervised 12 students. |
Presentations and Courses
Oct 1994 | Cold Spring Harbor Workshop, Analysis and genetic manipulation of yeast artificial chromosomes (YACs), Cold Spring Harbor Laboratory, NY, USA |
Sep 1999 | EMBO Workshop: Lymphocyte Development, Basel Institute of Immunology, Switzerland |
July 2000 | EMBO Workshop: Application of Advanced Digital Microscopy in Molecular Cell Biology, The Weizmann Institute of Science, Rehovot, Israel |
Sep 2000 | EFIS European Immunology Conference, Poznan, Poland. Oral presentation& Poster: Invariant Chain N-terminal domain induces B cell Maturation by activating NF-kB/TAFII105 transcription program. |
Sep 2001 | 11th International Congress of Immunology, Stockholm, Sweden. Poster: Invariant chain lacking its lumenal domain induces B cell maturation in a process mediated by NF-kB. |
Oct 2004 | Cancer Vaccines conference. New York. USA. Poster: The AHNAKs-giant regulators of calcium signaling in the immune system. |
Sep 2005 | 22nd Microelectrode Techniques for Cell Physiology Workshop, Marine Biological Association (MBA), Plymouth, UK. |
Apr 2006 | Gene Expression and signaling in the immune system, Cold Spring Harbor, New York, USA. Poster: A giant protein, AHNAK is required for calcium signaling during T cell activation. |
Jan 2014 | Society of Thoracic Surgery (STS) 50th Annual Meeting, Orlando, Florida, USA. |